Super mutant new vegas

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Used before and after Fallout's Great War in multiple ways, it began as a Super Soldier program of sorts before becoming the full-blown source of Super Mutants.

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These creatures were created due to exposure to the Forced Evolutionary Virus, which itself has come in a variety of strains and implementations in the past. In general, a Super Mutant is a hulking humanoid (compared to regular humans, though not all are of equal size) with enhanced strength, physical capabilities, disease and radiation resistances, and more. Appearing in the original game as a unique mutant enemy led by the Master, super mutants have since become more and more varied.